NOD.Cg-Prkdcscid/J
Mice homozygous for the severe combined immune deficiency spontaneous mutation Prkdcscid, commonly referred to as scid, are characterized by an absence of functional T cells and B cells, lymphopenia, hypogammaglobulinemia, and a normal hematopoietic microenvironment.
Prkdcscid mice accept allogeneic and xenogeneic grafts making them an ideal model for cell transfer experiments.
Some scid mice will spontaneously develop partial immune reactivity.
scid mice that have serum Ig levels greater than 1 ug/ml are considered "leaky". scid leakiness is highly strain dependent, increases with age, and is higher in mice housed under non-SPF conditions. In general, Prkdcscid leakiness is low on the NOD/ShiLtSz genetic background.
Scid mice carry a DNA repair defect and a defect in the rearrangement of genes that code for antigen-specific receptors on lymphocytes.
Thymic lymphomas occur with high frequency in this strain.
The life span is typically limited to only 8.5 months under specific pathogen-free conditions.
| AGE | Female | Male | ||
| Import price | Indian price | Import price | Indian price | |
| 3 Weeks | $149.03 | $147.56 | ||
| 4 Weeks | $149.03 | $147.56 | ||
| 5 Weeks | $153.62 | $152.15 | ||
| 6 Weeks | $158.20 | $156.73 | ||
| 7 Weeks | $162.79 | $161.32 | ||
| 8 Weeks | $167.38 | $165.89 | ||
| 9 Weeks | $171.96 | N/A | ||
| 10 Weeks | $176.55 | N/A | ||
| Age (weeks) | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | |
| Male | Mean | 11.1 | 19.0 | 21.6 | 23.0 | 24.5 | 25.3 | 26.6 | 26.3 |
| St Dev | 2.6 | 2.5 | 1.7 | 1.8 | 1.8 | 1.8 | 1.9 | 1.8 | |
| N | 80 | 79 | 79 | 79 | 79 | 77 | 77 | 77 | |
| Female | Mean | 10.4 | 15.9 | 17.5 | 18.6 | 19.5 | 20.1 | 20.4 | 20.6 |
| St Dev | 2.4 | 1.7 | 1.4 | 1.4 | 1.3 | 1.3 | 1.2 | 1.4 | |
| N | 80 | 80 | 80 | 80 | 80 | 80 | 80 | 80 | |
| Age (weeks) | 11 | 12 | 13 | 14 | 15 | 16 | |
| Male | Mean | 27.7 | 28.2 | 28.4 | 29.0 | 29.0 | 29.7 |
| St Dev | 1.8 | 1.9 | 2.0 | 2.0 | 2.1 | 2.4 | |
| N | 77 | 77 | 76 | 75 | 75 | 73 | |
| Female | Mean | 21.0 | 21.7 | 21.4 | 21.8 | 21.8 | 21.9 |
| St Dev | 1.2 | 1.2 | 1.3 | 1.3 | 1.1 | 1.2 | |
| N | 80 | 80 | 80 | 80 | 79 | 79 | |
For more detailed information please visit https://www.jax.org/strain/001303